АЛГОРИТМ ПРЕДСКАЗАНИЯ ВЗАИМОДЕЙСТВИЯ БЕЛКОВ НА ОСНОВЕ СТРУКТУРНОЙ ГОМОЛОГИИ
Abstract
Предлагается оригинальный алгоритм предсказания взаимодействия белков, основанный на
структурной схожести с экспериментально определенным интерфейсом белкового комплекса, отобранным из базы интерфейсов белковых комплексов. Пара свободных белков выравнивается на интерфейс из библиотеки белок-белковых интерфейсов. Выравнивание выполняется с помощью метода динамического программирования путем максимизации корреляции между матрицами расстояний отрезков интерфейса и белка.
About the Authors
Т. Кирис
Объединенный институт проблем информатики НАН Беларуси
Belarus
Belarus
А. Тузиков
Объединенный институт проблем информатики НАН Беларуси
Belarus
Belarus
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ISSN 2617-6963 (Online)
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