АЛГОРИТМ ПРЕДСКАЗАНИЯ ВЗАИМОДЕЙСТВИЯ БЕЛКОВ НА ОСНОВЕ СТРУКТУРНОЙ ГОМОЛОГИИ
Аннотация
Предлагается оригинальный алгоритм предсказания взаимодействия белков, основанный на
структурной схожести с экспериментально определенным интерфейсом белкового комплекса, отобранным из базы интерфейсов белковых комплексов. Пара свободных белков выравнивается на интерфейс из библиотеки белок-белковых интерфейсов. Выравнивание выполняется с помощью метода динамического программирования путем максимизации корреляции между матрицами расстояний отрезков интерфейса и белка.
Об авторах
Т. В. Кирис
Объединенный институт проблем информатики НАН Беларуси
Беларусь
Беларусь
А. В. Тузиков
Объединенный институт проблем информатики НАН Беларуси
Беларусь
Беларусь
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Рецензия
Для цитирования:
Кирис Т.В., Тузиков А.В. АЛГОРИТМ ПРЕДСКАЗАНИЯ ВЗАИМОДЕЙСТВИЯ БЕЛКОВ НА ОСНОВЕ СТРУКТУРНОЙ ГОМОЛОГИИ. Информатика. 2012;(4(36)):36-44.
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