<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">inform</journal-id><journal-title-group><journal-title xml:lang="ru">Информатика</journal-title><trans-title-group xml:lang="en"><trans-title>Informatics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1816-0301</issn><issn pub-type="epub">2617-6963</issn><publisher><publisher-name>UIIP NASB</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">inform-367</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МАТЕМАТИЧЕСКОЕ МОДЕЛИРОВАНИЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>MATHEMATICAL MODELING</subject></subj-group></article-categories><title-group><article-title>МОДЕЛИРОВАНИЕ ПРОТОКОЛА ЛЕЧЕНИЯ ДЕТЕЙ С АГАММАГЛОБУЛИНЕМИЕЙ</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Красько</surname><given-names>О. В.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Углова</surname><given-names>Т. А.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алешкевич</surname><given-names>С. Н.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Объединенный институт проблем информатики НАН Беларуси</institution><country>Belarus</country></aff><aff xml:lang="ru" id="aff-2"><institution>Республиканский научно-практический центр детской онкологии и гематологии</institution><country>Belarus</country></aff><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>19</day><month>04</month><year>2018</year></pub-date><volume>0</volume><issue>2(30)</issue><fpage>63</fpage><lpage>71</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Красько О.В., Углова Т.А., Алешкевич С.Н., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Красько О.В., Углова Т.А., Алешкевич С.Н.</copyright-holder><copyright-holder xml:lang="en">Красько О.В., Углова Т.А., Алешкевич С.Н.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://inf.grid.by/jour/article/view/367">https://inf.grid.by/jour/article/view/367</self-uri><abstract><p>Исследуется стохастическая модель терапии пациентов с врожденной агаммаглобулинемиейна основе ретроспективных данных, предоставленных Республиканским научно-практическим центром детской онкологии и гематологии (РНПЦДОГ). На основе результатов моделирования разрабатываются рекомендации по протоколу лечения.</p></abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Primary immunodeficiency diseases. Report of IUIS scientific committee. International</mixed-citation><mixed-citation xml:lang="en">Primary immunodeficiency diseases. Report of IUIS scientific committee. International</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Union of Immunological Societies. Clin. Exp. Immunol. – 1999. – Vol. 118 (Suppl. 1). – P. 1–28.</mixed-citation><mixed-citation xml:lang="en">Union of Immunological Societies. Clin. Exp. Immunol. – 1999. – Vol. 118 (Suppl. 1). – P. 1–28.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Резник, И.Б. Иммунодефицитные состояния генетической природы: новый взгляд на</mixed-citation><mixed-citation xml:lang="en">Резник, И.Б. Иммунодефицитные состояния генетической природы: новый взгляд на</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">проблему / И.Б. Резник // Русский мед. журнал. – 1998. – № 9. – С. 3–10.</mixed-citation><mixed-citation xml:lang="en">проблему / И.Б. Резник // Русский мед. журнал. – 1998. – № 9. – С. 3–10.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Ballow, M. Primary immunodeficiency disorders: antibody deficiency / M. Ballow //</mixed-citation><mixed-citation xml:lang="en">Ballow, M. Primary immunodeficiency disorders: antibody deficiency / M. Ballow //</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">J. Allergy Clin. Immunol. – 2002. – Vol. 109. – P. 581–591.</mixed-citation><mixed-citation xml:lang="en">J. Allergy Clin. Immunol. – 2002. – Vol. 109. – P. 581–591.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Champi, C. Primary immunodeficiency disorders in children: prompt diagnosis can lead to</mixed-citation><mixed-citation xml:lang="en">Champi, C. Primary immunodeficiency disorders in children: prompt diagnosis can lead to</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">lifesaving treatment / C. Champi // J. Pediatr Health Care. – 2002. – Vol. 16. – P. 16–21.</mixed-citation><mixed-citation xml:lang="en">lifesaving treatment / C. Champi // J. Pediatr Health Care. – 2002. – Vol. 16. – P. 16–21.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Sorensen, R.U. Antibody deficiency syndromes / R.U. Sorensen, C. Moore // Pediatr. Clin.</mixed-citation><mixed-citation xml:lang="en">Sorensen, R.U. Antibody deficiency syndromes / R.U. Sorensen, C. Moore // Pediatr. Clin.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">North Am. – 2000. – Vol. 47. – P.1225–1252.</mixed-citation><mixed-citation xml:lang="en">North Am. – 2000. – Vol. 47. – P.1225–1252.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Sacher, R.A. Safety and tolerability considerations with IGIV use / R.A. Sacher // IGIV therapy:</mixed-citation><mixed-citation xml:lang="en">Sacher, R.A. Safety and tolerability considerations with IGIV use / R.A. Sacher // IGIV therapy:</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">clinical and pharmaceutical considerations for 2006. Symp. News Reporter, 2006, February. –</mixed-citation><mixed-citation xml:lang="en">clinical and pharmaceutical considerations for 2006. Symp. News Reporter, 2006, February. –</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Oxford University Press, 1999. – P. 1–28.</mixed-citation><mixed-citation xml:lang="en">Oxford University Press, 1999. – P. 1–28.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Аверченков, В.И. Внутривенные иммуноглобулины: механизм действия и возможности</mixed-citation><mixed-citation xml:lang="en">Аверченков, В.И. Внутривенные иммуноглобулины: механизм действия и возможности</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">клинического применения / В.И. Аверченков, И.С. Палагин // Клиническая микробиологическая антимикробная химиотерапия. – 2004. – № 3. – С. 273–281.</mixed-citation><mixed-citation xml:lang="en">клинического применения / В.И. Аверченков, И.С. Палагин // Клиническая микробиологическая антимикробная химиотерапия. – 2004. – № 3. – С. 273–281.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Косарев, В.В. Клиническая фармакология / В.В. Косарев, В.С. Лотков, С.А. Бабанов. –</mixed-citation><mixed-citation xml:lang="en">Косарев, В.В. Клиническая фармакология / В.В. Косарев, В.С. Лотков, С.А. Бабанов. –</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Ростов : Феникс, 2008. – 349 с.</mixed-citation><mixed-citation xml:lang="en">Ростов : Феникс, 2008. – 349 с.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Эконометрия / В.И. Суслов [и др.]. – Новосибирск : СО РАН, 2005. – 744 с.</mixed-citation><mixed-citation xml:lang="en">Эконометрия / В.И. Суслов [и др.]. – Новосибирск : СО РАН, 2005. – 744 с.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Дрейпер, Н. Прикладной регрессионный анализ. В 2-х кн. Кн. 1 / Н. Дрейпер, Г. Смит. –</mixed-citation><mixed-citation xml:lang="en">Дрейпер, Н. Прикладной регрессионный анализ. В 2-х кн. Кн. 1 / Н. Дрейпер, Г. Смит. –</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">М. : Финансы и статистика, 1986. – 366 с.</mixed-citation><mixed-citation xml:lang="en">М. : Финансы и статистика, 1986. – 366 с.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">The effect of two different dosages of intravenous immunoglobulin on the incidence of recurrent infections in patients with primary hypogammaglobulinemia / H.W. Eljkhout [et al.] // Ann. Intern. Med. – 2001. – Vol. 135. – P. 165–174.</mixed-citation><mixed-citation xml:lang="en">The effect of two different dosages of intravenous immunoglobulin on the incidence of recurrent infections in patients with primary hypogammaglobulinemia / H.W. Eljkhout [et al.] // Ann. Intern. Med. – 2001. – Vol. 135. – P. 165–174.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Lemieux, R.С. Therapeutic intravenous immunoglobulins : review / R.С. Lemieux,</mixed-citation><mixed-citation xml:lang="en">Lemieux, R.С. Therapeutic intravenous immunoglobulins : review / R.С. Lemieux,</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">R. Bazin, S. Neron // Mol. Immunol. – 2005. – Vol. 42. – P. 839– 887.</mixed-citation><mixed-citation xml:lang="en">R. Bazin, S. Neron // Mol. Immunol. – 2005. – Vol. 42. – P. 839– 887.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
