informИнформатикаInformatics1816-03012617-6963UIIP NASBinform-142Research ArticleИНФОРМАЦИОННЫЕ ТЕХНОЛОГИИINFORMATION TECHNOLOGYАНАЛИЗ ЭКСПРЕССИИ ГЕНОВ В РЕЗУЛЬТАТЕ ВОЗДЕЙСТВИЯ ИНТЕРФЕРОНА IFN-γ НА КЛЕТКУ С ИСПОЛЬЗОВАНИЕМ ПРОГРАММНОГО ПАКЕТА GeneExpressionAnalyserANALYSIS OF CELLULAR REACTION TO IFN-γ STIMULATION BY A SOFTWARE PACKAGE GeneExpressionAnalyserСаечниковА. В.SaetchnikovA. V.saetchnikov.anton@tut.byЯцковН. Н.YatskouM. M.face@neicon.ruНазаровП. В.NazarovP. V.petr.nazarov@crp-sante.luВалларЛ.VallarL.face@neicon.ruАпанасовичВ. В.ApanasovichV. V.face@neicon.ruБелорусский государственный университетBelarusЦентр геномных исследованийLuxembourgБелорусский государственный университетБелорусский государственный университет201404102016028497Copyright © Саечников А.В., Яцков Н.Н., Назаров П.В., Валлар Л., Апанасович В.В., 20162016Саечников А.В., Яцков Н.Н., Назаров П.В., Валлар Л., Апанасович В.В.Saetchnikov A.V., Yatskou M.M., Nazarov P.V., Vallar L., Apanasovich V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://inf.grid.by/jour/article/view/142

Предлагается программный пакет GeneExpressionAnalyser для анализа данных, полученных в ходе проведения экспериментов с использованием биочипов ДНК. Детально рассмотрены алгоритмы предварительного анализа данных, выделения дифференциально-выраженных генов и анализа биологических функций клетки. Работоспособность пакета исследуется на примере опубликованных экспериментальных данных, представляющих результаты эксперимента по ис-следованию изменений экспрессии генов в клетке меланомы под воздействием интерферона IFN-? с течением времени.

The software package GeneExpressionAnalyser for analysis of the DNA microarray experi-mental data has been developed. The algorithms of data analysis, differentially expressed genes and biological functions of the cell are described. The efficiency of the developed package is tested on the published experimental data devoted to the time-course research of the changes in the human cell un-der the influence of IFN-γ on melanoma. The developed software has a number of advantages over the existing software: it is free, has a simple and intuitive graphical interface, allows to analyze different types of DNA microarrays, contains a set of methods for complete data analysis and performs effec-tive gene annotation for a selected list of genes.

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The authors declare that there are no conflicts of interest present.