informИнформатикаInformatics1816-03012617-6963UIIP NASBinform-108Research ArticleОБРАБОТКА СИГНАЛОВ, ИЗОБРАЖЕНИЙ, РЕЧИ, ТЕКСТА И РАСПОЗНАВАНИЕ ОБРАЗОВSIGNAL, IMAGE, SPEECH, TEXT PROCESSING AND PATTERN RECOGNITIONПОИСК ВЗАИМОСВЯЗЕЙ МЕЖДУ ЛЕКАРСТВЕННОЙ УСТОЙЧИВОСТЬЮ И МОРФОЛОГИЕЙ ИЗОБРАЖЕНИЙ ПРИ ТУБЕРКУЛЕЗЕEXAMINATION OF POSSIBLE LINKS BETWEEN DRUG RESISTANCE AND MORPHOLOGY OF LUNG IMAGES OF TUBERCULOSIS PATIENTSКовалевВ. А.KovalevV. A.assili.kovalev@gmail.comЛевчукВ. А.LiauchukV. A.СафоновИ. В.SafonauI. U.ТарасовО. В.TarasauA. U.Объединенный институт проблем информатики НАН БеларусиRussian FederationРеспубликанский научно-практический центр пульмонологии и фтизиатрииRussian Federation201301102016041322Copyright © Ковалев В.А., Левчук В.А., Сафонов И.В., Тарасов О.В., 20162016Ковалев В.А., Левчук В.А., Сафонов И.В., Тарасов О.В.Kovalev V.A., Liauchuk V.A., Safonau I.U., Tarasau A.U.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://inf.grid.by/jour/article/view/108

Приводятся результаты исследований, направленных на поиск взаимосвязей между лекарственной устойчивостью(ЛУ) туберкулеза легких и структурными признаками рентгеновских и компь-ютерно-томографических(КТ)изображений легкого. Представлена многоступенчатая процедура, включающая в себя вычисление признаков изображений, извлечение главных компонент, корреляцию главных компонент с клиническими данными пациентов, а такжеобратное отображениестатисти-чески значимых компонент на исходные признаки и далее – на исходные изображения с целью выделе-ния соответствующих ключевых структурных образований. Проводится детальный статистиче-ский анализ взаимосвязей между степенью ЛУ и признаками изображений, включающий нахождение однофакторных корреляций, поиск многофакторных связей и проведение детальных кросс-проверок.

The purpose of this paper is to present the results of an exploratory study of possible correlations between the drug resistance and the structural features of CT and X-ray images of lungtuberculosis patients. A multi-step procedure is suggested which includes calculation of textural image features, extracting their principal components, correlating them to patients’ clinical data and mapping the significant principal components back to image descriptor elements and then to the corresponding image structures they found to be linked with. The results of a detailed statistical analysis of the revealed links between the drug resistance and the image features are presented. The analysis includes findingone-factor correlations, performing multivariate regression analysis and cross-validation.

ReferencesFerguson, L.A. Multidrug-resistant and extensively drug-resistant tuberculosis : The new face of an old disease / L.A. Ferguson, J. Rhoads // Journal of American Academy Nurse Practitioners. – 2009. – Vol. 21, № 11. – P. 603–609.Ferguson, L.A. Multidrug-resistant and extensively drug-resistant tuberculosis : The new face of an old disease / L.A. Ferguson, J. Rhoads // Journal of American Academy Nurse Practitioners. – 2009. – Vol. 21, № 11. – P. 603–609.Chiang, C.Y. Drug-resistant tuberculosis: Past, present, future / C.Y. Chiang, R. Centis, G.B. Migliori // Respirology. – 2010. – Vol. 15, № 3. – P. 413–432.Chiang, C.Y. Drug-resistant tuberculosis: Past, present, future / C.Y. Chiang, R. Centis, G.B. Migliori // Respirology. – 2010. – Vol. 15, № 3. – P. 413–432.Multidrug-resistant tuberculosis in Belarus: the size of the problem and associated risk factors / A. Skrahina [et al.] // Bulletin of the World Health Organization. – 2013. – Vol. 91. – P. 36–45.Multidrug-resistant tuberculosis in Belarus: the size of the problem and associated risk factors / A. Skrahina [et al.] // Bulletin of the World Health Organization. – 2013. – Vol. 91. – P. 36–45.Belarus Tuberculosis Portal [Электронный ресурс]. – Режим доступа :http://tuberculosis.by. – Дата доступа : 20.02.2013.Belarus Tuberculosis Portal [Электронный ресурс]. – Режим доступа :http://tuberculosis.by. – Дата доступа : 20.02.2013.Radiological Findings of Extensively Drug-Resistant Pulmonary Tuberculosis in Non-AIDS Adults : Comparisons with Findings of Multidrug-Resistant and Drug-Sensitive Tuberculosis / J. Cha [et al.] // Korean Journal of Radiology. – 2009. – Vol. 10. – P. 207–216.Radiological Findings of Extensively Drug-Resistant Pulmonary Tuberculosis in Non-AIDS Adults : Comparisons with Findings of Multidrug-Resistant and Drug-Sensitive Tuberculosis / J. Cha [et al.] // Korean Journal of Radiology. – 2009. – Vol. 10. – P. 207–216.Computed Tomography Features of Extensively Drug-Resistant Pulmonary Tuberculosis in Non-HIV-Infected Patients / E.S. Lee [et al.] // Journal of Computer Assisted Tomography. – 2010. – Vol. 34. – P. 559–563.Computed Tomography Features of Extensively Drug-Resistant Pulmonary Tuberculosis in Non-HIV-Infected Patients / E.S. Lee [et al.] // Journal of Computer Assisted Tomography. – 2010. – Vol. 34. – P. 559–563.Three-dimensional texture analysis of MRI brain datasets / V.A. Kovalev [et al.] // IEEE Transactions on Medical Imaging. – 2001. – Vol. 20, № 5. – P. 424–433.Three-dimensional texture analysis of MRI brain datasets / V.A. Kovalev [et al.] // IEEE Transactions on Medical Imaging. – 2001. – Vol. 20, № 5. – P. 424–433.A method for identification and visualization of histological image structures relevant to the cancer patient conditions / V.A. Kovalev [et al.] // Proc. of the 27-th Int. congress on Computer Analysis of Images and Patterns (CAIP-2011). – Spain, 2011. – Vol. 6854, № 1. – P. 460–468.A method for identification and visualization of histological image structures relevant to the cancer patient conditions / V.A. Kovalev [et al.] // Proc. of the 27-th Int. congress on Computer Analysis of Images and Patterns (CAIP-2011). – Spain, 2011. – Vol. 6854, № 1. – P. 460–468.Kovalev, V.A. Gender and age effects in structural brain asymmetry as measured by MRI texture analysis / V.A. Kovalev, F. Kruggel, D.Y. von Cramon // NeuroImage. – 2003. – Vol. 19. – P. 896–905.Kovalev, V.A. Gender and age effects in structural brain asymmetry as measured by MRI texture analysis / V.A. Kovalev, F. Kruggel, D.Y. von Cramon // NeuroImage. – 2003. – Vol. 19. – P. 896–905.Kaiser, H.F. The application of electronic computers to factor analysis / H.F. Kaiser // Educational and Psychological Measurement. – 1960. – Vol. 20. – P. 141–151.Kaiser, H.F. The application of electronic computers to factor analysis / H.F. Kaiser // Educational and Psychological Measurement. – 1960. – Vol. 20. – P. 141–151.Sapsford, R. Data Collection and Analysis / R. Sapsford, V. Jupp. – London : Sage, 2006. – 332 p.Sapsford, R. Data Collection and Analysis / R. Sapsford, V. Jupp. – London : Sage, 2006. – 332 p.Kohavi, R. A study of cross-validation and bootstrap for accuracy estimation and model selection / R. Kohavi // Proc. of the Fourteenth Int. Joint Conf. on Artificial Intelligence (IJCAI'95). – USA, 1995. – Vol. 2. – P. 1137–1143.Kohavi, R. A study of cross-validation and bootstrap for accuracy estimation and model selection / R. Kohavi // Proc. of the Fourteenth Int. Joint Conf. on Artificial Intelligence (IJCAI'95). – USA, 1995. – Vol. 2. – P. 1137–1143.

The authors declare that there are no conflicts of interest present.